The Daggers were unable to spring a surprise at promotion chasers Oxford United, going down 4-0 at the Kassam Stadium.
The visitors made four changes from Saturday’s game, with Dom Hyam, Joss Labadie
, Ashley Chambers
and Oliver Hawkins all coming into the starting line-up.
There was also a place on the bench for defender Quade Taylor, who joined on loan until the end of the season from Bolton Wanderers in the hours before the game.
Liam O’Brien was called upon to produce two good saves in the 13th minute, first denying Alex McDonald a solo goal and then Kemar Roofe with a placed shot.
The Daggers keeper was beaten two minutes later, though, as Roofe slid a shot in from 18 yards.
O’Brien was in the thick of the action 15 minutes later, producing a stunning double save to deny both Liam Sercombe and Roofe in quick succession.
The away keeper produced more good saves before the half was out, while Josh Passley
saw a long range effort saved by Benji Buchel.
Daggers were two behind in the 50th minute when Roofe struck again, pushing the ball beyond O’Brien and into the net.
Despite conceding again, Matty Cash saw two efforts from inside the box saved by Buchel in the space of a couple of minutes.
John Still brought Jamie Cureton
on as a replacement and it nearly worked as the evergreen striker shot just over from 18 yards in the 67th minute.
O’Brien produced more good saves to prevent Oxford from extending their lead, but he was beaten with a header from Alex McDonald 11 minutes from time.
And the hosts moved further clear five minutes from the end as Roofe completed his hat trick.